[KAID Members’ Discount: 135,000 → 120,000 KRW] Jong-Il Yoon – "PDRN for Dental Clinicians: A First Step Book "

Book Introduction

Modern dental practice has achieved remarkable progress over the past decades. Advances in tooth preservation, periodontal therapy, and a wide range of implant procedures have undoubtedly contributed to healthier, more functional oral environments, thereby extending human life expectancy. More recently, the integration of digital technologies has accelerated this progress, bringing dentistry to new heights.  As a clinician with more than 25 years of practice, I have continually marveled at these developments.

Yet, there remain situations that are difficult to resolve or outcomes that defy clear explanation. Recurrent intraoral inflammatory responses, unexplained implant failures, and peri-implantitis in long-standing implants often leave clinicians questioning their underlying causes and seeking appropriate treatment strategies. Many practitioners share similar experiences with patients whose clinical courses or prognoses remain disappointing and troublesome. When I first encountered PDRN (polydeoxyribonucleotide), I approached it lightly, assuming it might only benefit soft-tissue inflammation in the oral cavity.

However, the deeper my understanding grew, the more my perspective changed. Initially, like many other clinicians, I considered PDRN merely a supportive agent for soft-tissue inflammation. Gradually, through literature review and clinical observations, I realized that these DNA fragments could play a far broader role within the human body. In medicine, PDRN had already been applied across diverse fields, with an expanding body of scientific evidence. Motivated by these findings, I began exploring its wider clinical applications and observed remarkable outcomes in practice.

These results prompted further reflection on PDRN’s mechanisms and potential.
Continued study revealed that the essence of physiological homeostasis lies in immune regulation, and that DNA itself plays a central role in modulating the immune environment. Inflammation, while a protective defense against external threats, becomes problematic when unchecked or prolonged, leading to tissue damage. Because such excessive inflammation arises from dysregulated immune responses, eliminating external triggers and restoring immune balance within the body offers a path to fundamental control of inflammation and tissue repair.

Just as modern third-generation immunotherapies harness innate anti-cancer responses, the ideal strategy for inflammation and regeneration may lie in amplifying the body’s own defense and repair mechanisms, achieving effective and safe treatment without adverse effects. Using a construction analogy, while remarkable advances have been made in building structures above ground, there has been insufficient scientific attention to the “foundation”—our body—on which those structures must rest.

This book seeks to provide insight into such foundational approaches. Globally, research on immune regulation for oral diseases is expanding rapidly, and PDRN is emerging as one of the most promising and safe candidate agents. Although still relatively unfamiliar and in need of further research, even modest improvements in modulating the body’s immune environment can yield safer, more predictable outcomes and help resolve unexplained clinical problems.

If this book can serve as a useful guide in that direction, it will represent both an encouraging and significant step forward. As a first attempt, the work may have its limitations. Nevertheless, I hope it will inspire continued exploration, helping dentistry worldwide take yet another step forward.