[JDIR Issue (Practice-based dental implant loss analysis: 381 case series and 25 years of experience of one practitioner)]

1. Purpose
 To identify potential risk factors associated with dental implant failure based on a 25-year practice-based case series conducted by
 a single practitioner.

2. Methods
 Records of 381 dental implants placed in 118 patients between 2000 and 2023 were retrospectively analyzed.
 Variables examined included age, sex, systemic health conditions (such as diabetes and cardiovascular diseases),
 smoking status, implant size and shape, and type of restorative treatment. 
 Multivariate regression analysis was performed to evaluate relationships between potential risk factors and implant failure.

3. Results
 The frequency of implant failure ranged from 4% to 9%. No clear association was observed between implant failure and
 demographic factors, systemic health conditions, implant design, or restorative treatment type.
 Early failures were mainly related to lack of osseointegration, whereas late failures were primarily associated with peri-implantitis.

4. Conclusion
 The findings suggest that dental implant failure occurs in approximately 10% of implants and may be largely influenced by
 individual susceptibility rather than identifiable clinical risk factors.
 These results highlight the importance of preventive strategies and further research on biological susceptibility to peri-implantitis.